Redox-dependent gating of vdac by mitoneet
Web26. apr 2013 · Respiratory substrates and adenine nucleotides cross the mitochondrial outer membrane through the voltage-dependent anion channel (VDAC), comprising three isoforms--VDAC1, 2, and 3. We characterized the role of individual isoforms in mitochondrial metabolism by HepG2 human hepatoma cells using siRNA … Web11. sep 2024 · Human mitoNEET (mNT) is the first identified Fe–S protein of the mammalian outer mitochondrial membrane. Recently, we demonstrated the involvement of mNT in a specific cytosolic pathway dedicated to the reactivation of oxidatively damaged cytosolic aconitase by cluster transfer.
Redox-dependent gating of vdac by mitoneet
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Web1. aug 2024 · VDAC1 and 2 were identified as ME-344 targets in H460 cells by using click chemistry and mass spectrometry. Affinity-enriched and gel-fractionated proteins between 10 and 250 kDa were analyzed by LC/MS-MS and quantified by label-free proteomics. WebThe Voltage-Dependent Anion-selective Channel (VDAC) is the pore-forming protein of mitochondrial outer membrane, allowing metabolites and ions exchanges. In …
WebWe find that the redox-sensitive [2Fe-2S] cluster protein mitoNEET gates VDAC1 when mitoNEET is oxidized. Addition of the VDAC inhibitor 4,4′-diisothiocyanatostilbene-2,2′-disulfonate (DIDS) prevents both mitoNEET binding in vitro and mitoNEET-dependent mitochondrial iron accumulation in situ. WebIsoliquiritigenin Induces Mitochondrial Dysfunction and Apoptosis by Inhibiting mitoNEET in a Reactive Oxygen Species-Dependent Manner in A375 Human Melanoma Cells (2024) …
WebIn the outer mitochondrial membrane, the voltage-dependent anion channel 1 (VDAC1) functions in cellular Ca2+ homeostasis by mediating the transport of Ca2+ in and out of mitochondria. VDAC1 is... WebWe find that the redox-sensitive [2Fe-2S] cluster protein mitoNEET gates VDAC1 when mitoNEET is oxidized. Addition of the VDAC inhibitor 4,4′-diisothiocyanatostilbene-2,2′ …
Web29. jan 2024 · MitoNEET contains redox-sensitive 2Fe-2S clusters 9, 10, and under oxidized state, it can transfer its 2Fe-2S clusters to an apo-acceptor protein 11, 12, 13. Recently, it has been shown that...
Webthe voltage-dependent anion channel (VDAC) and regulate its gating in a redox-dependent manner. These findings have im-plications for ferroptosis, apoptosis, and iron metabolism … hypertrophy pull workoutWeb16. sep 2024 · Redox-Dependent Gating of VDAC by mitoNEET Proceedings of the National Academy of Sciences of the United States of America - United States doi … hypertrophy prostate icd 10 codeWeb1. nov 2009 · Here we have observed for the first time that two members of the TZD drug family similarly affect mitoNEET redox chemistry: pK ox increases by ~2 units, resulting in a lowering of E m,7 by > 100mV. Thus, drug binding has a fundamental impact on the redox activity of mitoNEET. ... Redox-dependent gating of VDAC by mitoNEET. Lipper CH, … hypertrophy rest periodWebThe voltage-dependent anion channel (VDAC) is one of the most highly abundant proteins found in the outer mitochondrial ... on its structure, discussing various models proposed for voltage gating as well as potential drug targets to modulate the ... based on VDAC’s interaction with mitoNEET, the channel’s involvement in ferroptosis has also ... hypertrophy range of resistance traininghttp://www3.mpibpc.mpg.de/groups/de_groot/pdf/Najbauer_EBJ_2024.pdf hypertrophy redditWeb@article{Lipper2024RedoxdependentGO, title={Redox-dependent gating of VDAC by mitoNEET}, author={Colin H. Lipper and Jason T. Stofleth and Fang Bai and Yang Sung … hypertrophy push dayWeb1. jan 2014 · Mitochondrial VDAC1 was purified from rat brain as per the standard procedure. 31, 32 Briefly, the brain of euthanized Wistar rats was removed and placed in solution A [250 mM Sucrose, 0.1 mM... hypertrophy retina