WebOct 15, 2024 · Synthesis method of indenone (Rec1 and Rec2, Scheme 2) from starting materials (various benzaldehydes) by Perkin reaction, hydrogenation and Friedel-Crafts reaction was described in our previous papers (see Scheme 2), and the characterization of compounds 1, 2, 4a and 10 were also shown in our published papers [23, 27, 28].The … WebThe present invention is related to new compounds as Sulindac derivatives for the treatment of cancer. BACKGROUND The anti-inflammatory, analgesic and antipyretic drugs are an …
Thieme E-Journals - Synlett / Abstract
WebFeb 16, 2024 · Further, Sulindac analog K-80003, designed and synthesized as described herein, exhibits increased affinity to RXRα without COX inhibitory activity, and displays enhanced efficacy in inhibiting tRXRα-dependent AKT … WebJun 18, 2024 · Sulindac is used for: Reducing pain, joint stiffness and swelling due to arthritis. Treatment of arthritis of the spine; Treatment of gouty arthritis; Treatment of shoulder bursitis; Treatment of shoulder … ohakune location
US Patent Application for Sulindac Derivatives for Treatment of …
WebJan 1, 1984 · It highlights its description, physical properties, synthesis, and method of analysis. Sulindac is a new nonsteroid anti-inflammatory drug with analgesic and antipyretic activity. It is an odorless, yellow crystalline powder. WebApr 19, 2024 · The general synthetic route for the preparation of oxazole and thiazole carboxylic acids is given in Figure 3 [ 42 ]. The α-amido-β-ketoester, prepared by the HATU catalyzed amide coupling of sulindac and ethyl 2-amino-3-oxo-3-phenylpropanoate, was used as the common intermediate for the synthesis of both targets. Figure 3. WebEffects of sulindac on renal function and prostaglandin synthesis in patients with moderate chronic renal insufficiency The renal effects of therapeutic doses of sulindac were studied in nine patients with stable renal insufficiency, mean creatinine clearance 37.0 +/- 2.2 ml min-1 1.73 m-2 (range 24.7-54.6 ml min-1 1.73 m-2). ohakune freedom camping