Thioamitides
WebThioholgamides are ribosomally synthesized and post-translationally modified peptides (RiPPs) with potent activity against cancerous cell lines and an unprecedented structure. Despite being one of the most structurally and chemically complex RiPPs, very few biosynthetic steps have been elucidated. Here, we report the complete in vitro … WebFeb 16, 2024 · Thioamitides are apoptosis-inducing ribosomally synthesized and post-translationally modified peptides (RiPPs) with substantial post-translational modifications (PTMs), whose biosynthetic details remain elusive.
Thioamitides
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WebThe thioamitides are one of the most structurally complex RiPP families, yet very few thioamitide biosynthetic steps have been elucidated, even though the gene clusters of multiple thioamitides ... WebDec 17, 2024 · The thioamitides are one of the most structurally complex RiPP families, yet very few thioamitide biosynthetic steps have been elucidated, even though the gene …
WebAug 21, 2024 · Thioamitides are a group of ribosomally synthesized and post-translational modified peptides with potent antiproliferative and pro-apoptotic activities. Their … WebN. Kumagai, in Comprehensive Chirality, 2012 4.14.1 Introduction. Thioamides and allylic cyanides have received little attention in asymmetric catalysis and, until recently, only …
WebOct 17, 2024 · Here, we report a scalable platform that combines high-throughput bioinformatics with automated biosynthetic gene cluster refactoring for rapid evaluation of uncharacterized gene clusters. As a proof of concept, 96 RiPP gene clusters that originate from diverse bacterial phyla involving 383 biosynthetic genes are refactored in a high … Webthioamide. Any drug that inhibits the thyroid gland from making thyroid hormone. Examples include methimazole and propylthiouracil. Want to thank TFD for its existence? Tell a …
WebThioamide. A thioamide (rarely, thionamide, but also known as thiourylenes) is a functional group with the general structure R1−C (=S)−NR2R3, where R1, R2 and R3 are any groups …
WebThioamitides are ribosomally synthesized and posttranslationally modified peptide (RiPP) natural products that hold great potential in anticancer drug development. Members in … swantjemausWebApr 29, 2024 · Linaridins are a small but growing class of natural products belonging to the ribosomally synthesized and post-translationally modified peptide (RiPP) superfamily. The class A linaridins, exemplified by cypemycin, possess an unusual S-[(Z)-2-aminovinyl]-d-cysteine (AviCys) residue. Formation of the AviCys in cypemycin requires an oxidative … swantje gosauWebOct 16, 2024 · The Utilization of Lanthipeptide Synthetases Is a General Strategy for the Biosynthesis of 2-Aminovinyl-Cysteine Motifs in Thioamitides ** basecamp pmWebDec 17, 2024 · Thiostreptamide S4 is a thioamitide, a family of promising antitumour ribosomally synthesised and post-translationally modified peptides (RiPPs). The thioamitides are one of the most structurally complex RiPP families, yet very few thioamitide biosynthetic steps have been elucidated, even though the gene clusters of multiple … swantje kornau hebammeWebApr 13, 2024 · Abstract The hot spring microbiome is a complex assemblage of micro- and macro-organisms; however, the understanding and projection of enzymatic repertoire that access earth’s integral ecosystem processes remains ambivalent. Here, the Khirganga hot spring characterized with white microbial mat and ions rich in sulfate, chlorine, sodium, … swantje jacklofskyWebthioamitides, a structurally complex family of ribosomally syn-thesised and post-translationally modi ed peptides2 (RiPPs). RiPPs derive from a ribosomally synthesised … basecamp plusWebJan 25, 2024 · The Utilization of Lanthipeptide Synthetases Is a General Strategy for the Biosynthesis of 2-Aminovinyl-Cysteine Motifs in Thioamitides* Angew Chem Int Ed Engl . … swantje knopke