Thiotetronate
WebThiolactomycin (retention time 27.14 min) production was lost, with no obvious new UV-absorbing peak, upon disruption of tlmD1 . (B) Further LC-ESI-HRMS analysis of the ΔstuD2 intermediate by selective ion monitoring confirmed it as thiotetromycin ( 2 ) (Fig. S20 ). Asterisk denotes not detected. WebJan 1, 2024 · In this application, we propose a multidisciplinary project involving heterologous biosynthesis, mechanistic enzymology, atomic resolution protein X-ray crystallography,chemoenzymaticsynthesis,andgeneticengineeringtounderstandandcontrol themolecularbasisofpolyketidediversificationinaseriesofmarinebacterialcompoundswith …
Thiotetronate
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WebSpirotetronate antibiotics, 213, 214 which exhibit a wide variety of biological activities, are a large class of natural products characterized by a tetronate unit that is spiro-conjugated … Web(Elements & Compounds) any of a class of sulphur-containing organic compounds with the formula RSH, where R is an organic group. Also called (not in technical usage): mercaptan
WebView history. Tools. α-, β-, γ-, and δ-lactones (left to right) Thiolactones are a class of heterocyclic compounds in organic chemistry. They are analogs of the more common … Webfor thiotetronate ring formation.5,6 Indeed, genes A, B, D 1,D 2, J and S are essential for thiotetronate formation, as proved by in vivo knock-out and complementation studies. 5 …
WebChemical 'chain termination' probes were utilised for the investigation of thiotetronate antibiotic biosynthesis in the filamentous bacteria Lentzea sp. Chemical 'chain termination' probes were utilised for the investigation of thiotetronate antibiotic biosynthesis in the filamentous bacteria Lentzea sp. and Streptomyces thiolactonus NRRL 15439. The use of … WebThiotetronate-containing natural products, including thiolactomycin, thiotetromycin, and thiotetroamide, are potent, broad-spectrum antibacterial compounds that target fatty acid synthesis in bacteria. Natural modifications at the C-5 dialkyl position in this molecular series result in pronounced bioactivity differences.
WebThe selective activation of unreactive hydrocarbons by biosynthetic enzymes has inspired new synthetic methods in C−H bond activation. Herein, we report the unprecedented …
WebJul 24, 2024 · The application of CRISPR/Cas9 system for genome editing in Streptomyces started in 2015, and since then related approaches have been tremendously developed. As shown in Table 1, diversified approaches are widely used to edit or refactor BGCs for NP drugs discovery and characterization. TABLE 1 TABLE 1. meals low in fat and carbsWebFollowing the in vivo investigation of thiotetronate assembly in Lentzea sp. and in S. thiolactonus NRRL 15439 (Havemann et al., Chem. Commun., 2024, DOI: 10.1039/c6cc09933e), the minimal set of genes required for thiolactomycin production was determined through heterologous expression and the mechanism for polyketide assembly … meals low in sugarWebThiolactomycin (TLM) is a thiotetronate antibiotic that selectively targets bacterial fatty acid biosynthesis through inhibition of the b-ketoacyl-acyl carrier protein synthases (KASI/II) that... meals lower triglyceridesWebChemistry Tree - Manuela Tosin Chemistry Tree: mentors, trainees, research areas and affiliations for researcher Log In Sign Up Log in to add people & connections, or click here to create an account. Save login - Forgot password Already have an account? Log in here. Login ID:Password:Re-enter:Email: pearltech learndirectpearlthane 11t85WebThiolactomycin (TLM) is a thiotetronate antibiotic that selectively targets bacterial fatty acid biosynthesis through inhibition of the b-ketoacyl-acyl carrier protein synthases (KASI/II) that catalyse chain elongation on the type II (dissociated) fatty acid synthase. pearlthane 11t85uvWebA genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis. Chem Sci. 2016 Jan 1;7(1):376-385. doi: 10.1039/c5sc03059e. Epub 2015 Oct 8. PubMed PMID: 28791099; PubMed Central PMCID: PMC5518548. 10: Tang X, Li J, Millán-Aguiñaga N, Zhang JJ, O'Neill EC, Ugalde JA, Jensen PR, Mantovani SM, Moore BS ... pearlthane